Mesa homebuyers are working with a $390,000 median price point, 7% below the national figure. Against the $65,000 median household income in the area, that's a 6.0x multiple.
At a 0.68% effective rate, Mesa property taxes add $221 to the monthly payment on the median home, $2,652 a year in total.
Arizona levies a state income tax on top of the $2,406/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Mesa's cost of living index is 102, above the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Mesa's median home price runs 7% lower than nearby Phoenix: $420,000 there versus $390,000 here.