Indiana has a cost of living index of 91 relative to the US average of 100. This is close to the national average. Indiana offers a typical cost structure — housing and expenses track closely to US median.
The 4% safe withdrawal rule suggests a FIRE number of 25x annual expenses. At Indiana's median income of $71,959, that is $1,798,975. However, if you plan to spend more (or less) than median income in retirement, scale the number accordingly.
Indiana taxes income at 2.95% flat. In FIRE, your primary income comes from portfolio withdrawals, dividends, and capital gains. Long-term capital gains in IN are taxed at the same rate as ordinary income, including IRA withdrawals. Factor this into your withdrawal rate planning.