$255,000 buys the median home in Columbia right now. With 20% down, that's a $51,000 down payment and a $204,000 loan, set against a $58,000 median household income.
At a 0.56% effective rate, Columbia property taxes add $119 to the monthly payment on the median home, $1,428 a year in total.
South Carolina levies a state income tax on top of the $1,548/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Columbia's cost of living index is 90, below the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Columbia's median home price runs 51% lower than nearby Charleston: $520,000 there versus $255,000 here.