Home prices in Redwood City run 400% above the national median: $2,100,000 versus $420,000. Relative to the $365,000 median household income here, the price-to-income ratio comes out to 5.8x.
Redwood City's 0.73% property tax rate runs below the 1.1% national average. That's $1,278/month on the median home here, not a rounding error against the mortgage payment.
California levies a state income tax on top of the $12,986/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Redwood City's cost of living index is 208, above the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Redwood City's median home price runs 135% higher than nearby Los Angeles: $895,000 there versus $2,100,000 here.