Statewide, Mississippi's median home price runs $175,000, 58% below the $420,000 national median. The 3.8x price-to-income ratio here is measured against a $46,500 median household income.
Mississippi's 0.81% average property tax rate runs below the 1.1% national average, working out to $118/month on the median home here.
Mississippi levies a state income tax of 0%–5% on top of the $1,103/month this mortgage runs. Model your real after-tax take-home before deciding how much payment you can carry.
Mississippi's cost of living index is 84, below the 100 national baseline. That's on top of the housing numbers above, not instead of them.
Mississippi's median home price runs 10% lower than Arkansas: $195,000 there versus $175,000 here.